Research shows that a brain circuit reinforces motor speed control

A brain circuit reinforces motor speed control

Brain stem neurons control spinal networks that control movement. Credits: Eva Berg

Researchers at Karolinska have discovered how brain circuits encode the onset, duration, and abrupt change of motor speed. The study was published in neuron.

Movement—”moving around” in the form of walking, running, or swimming—is a common behavior that allows us to interact with the world around us. Precise control over the start and duration of a movement phase, combined with the ability to make rapid changes in strength and speed, are key features for the versatility of movement. For example, we can suddenly change our movement speed from slow to running to adapt to our surroundings.

“Using the zebrafish as a model systemOur previous work revealed that neurons in spinal cord responsible for carrying out the movement assembled in Process consists of three modules, which act as gearshift mechanisms to increase speed,” said Abdel El Manira, Professor in the Department of Neuroscience and corresponding author of the paper.

“An outstanding question that remains unresolved is how upstream circuits, which reside in the brain stem, encode and transmit motor initiation, duration, and rate changes to executive circuits. this in the spinal cord.”

important discovery

By exploiting the relative accessibility of adult zebrafish, combined with a range of techniques, researchers are now able to reveal two brain circuit encodes the onset, duration, and abrupt change in motor speed.

The brain circuits represent the first step in a sequence of commands that encode the initiation, duration, speed, and strength of movement. Two lines of command are revealed here, with direct access to spinal circuits, allowing animals to navigate in their environment by grading the speed and strength of their locomotor movements, while controlling direction. These mechanisms in adult zebrafish can be extrapolated to mammalian model systems.

A brain circuit reinforces motor speed control

Abstract graphic. Credit: neuron (2022). DOI: 10.1016/j.neuron.2022.10.034

Connect map

The next step would be to map the connection between these brain circuits and those in the spinal cord that promote movement.

It is hoped that the circuit revealed in the study can guide the design of new therapeutic strategies for recovery motor function after spinal cord injury.

More information:
Eva M. Berg et al., Brainstem circuit initiation, swimming speed and duration in adult zebrafish, neuron (2022). DOI: 10.1016/j.neuron.2022.10.034

Provided by
Karolinska Academy

quote: Study showing brain circuitry underlying motor speed control (2022, Nov 25) retrieved Nov 27, 2022 from reveals-brain-circuit-underpinning-locomotor.html

This document is the subject for the collection of authors. Other than any fair dealing for private learning or research purposes, no part may be reproduced without written permission. The content provided is for informational purposes only.


News5s: Update the world's latest breaking news online of the day, breaking news, politics, society today, international mainstream news .Updated news 24/7: Entertainment, the World everyday world. Hot news, images, video clips that are updated quickly and reliably

Related Articles

Back to top button