Health

Re-examining the role of antibodies in childhood allergies


peanuts and eggs

Credit: Pixabay/CC0 Public Domain

According to a Northwestern Medicine study published in Medical science translation.

Scientists have checked Stool sample from more than 500 infants across the country and found that the presence of Immunoglobulin A, the most common antibody found in mucosa inside gastrointestinaldo not prevent peanuts or egg allergy develop later in life.

This finding raises questions about the role of Immunoglobulin A, or IgA, previously thought to be a protective factor against the development of food allergies.

Peanuts and eggs are the two most common allergens for babies and are estimated to affect one in 13 kids in the US, according to the Ann & Robert H. Lurie Children’s Hospital in Chicago.

Although previous research has shown that IgA can bind to and neutralize toxins and bacteria in the body, there is still no convincing evidence that IgA can do the same for pathogens. food allergies, says Stephanie Eisenbarth, MD, Ph.D., chief of Allergy and Immunology at the Institute. Faculty of Medicine and senior author of the study.

“We were able to work with different groups around the country to look at a number of groups of children and youth to ask: ‘Does the presence of IgA in peanuts tell us that a person can tolerate peanuts?’,” said Eisenbarth, director of the Center for Human Immunobiology and a member of the team. “We found that there really was no difference between kids with peanut allergies and kids without, and the same thing,” said Northwestern’s Robert H. Lurie, a member of the Northwestern Comprehensive Cancer Center. The same holds true for egg allergies.”

The findings come as allergy rates in children continue to rise: According to data from the Centers for Disease Control and Prevention, the number of children with allergies has more than doubled in the past 20 years.

Future research directions will focus on understanding the role of IgA in people who have undergone immunotherapy and develop tolerance to food allergens, Eisenbarth said.

“This study was made possible through the hard work of the lead author, Dr Elise Liu, and the amazing team of collaborators we have,” she said. “This is an impressive, multi-centre effort to try and answer this question. I really want to thank people from all over the United States for providing the samples and expertise to make this possible. reality.”

More information:
Elise G. Liu et al, Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens, Medical science translation (2022). DOI: 10.1126/scitranslmed.abq0599

quote: Re-examining the role of antibodies in childhood allergic disease (2022, December 2) retrieved December 4, 2022 from https://medicalxpress.com/news/2022-12-re -examining-antibodies-role-childhood-allergies.html

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