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MRI reveals significant brain abnormalities after COVID


MRI reveals significant brain abnormalities after COVID

Sensitivity-weighted imaging group analysis exhibited higher sensitivity-weighted imaging values ​​in the COVID group when compared with healthy controls. The three important clusters were found mainly in the white matter regions of the prefrontal cortex and in the brain stem. Clusters (a) and (b) are observed bilaterally in the cerebral white matter near the frontal orbital gyrus, while (c) are located in the midbrain region. Credit: RSNA and Sapna S. Mishra

Using a special type of MRI, researchers detected brain changes in patients within six months of their recovery from COVID-19, according to a study to be presented next week at World Health Research Institute. annual meeting of the Radiological Society of North America (RSNA).

About one-fifth of adults will grow long term effects from COVID-19, according to the US Centers for Disease Control and Prevention. Persistent COVID-related neurological symptoms include difficulty thinking or concentrating, headache, trouble sleeping, dizziness, tingling sensations, changes in smell or taste, and depression or anxiety. However, studies have found that COVID-19 can be associated with changes in the heart, lungs, or other organs even in asymptomatic patients.

As more and more people become infected and recover from COVID-19, research has begun to emerge, focusing on the long-term consequences of the disease.

For this study, the researchers used sensitive weighted imaging to analyze the impact of COVID-19 on the brain. Magnetic sensitivity indicates the extent to which certain materials, such as blood, iron and calcium, will be magnetized in an applied magnetic field. This capability aids in the detection and monitoring of a wide range of neurological conditions including microscopic bleeding, vascular malformations, brain tumors, and stroke.

“Previous group-level studies have not focused on changes in COVID-19 in magnetic sensitivity of the brain although some case reports signal such abnormalities,” said study co-author Sapna S. Mishra, a doctoral candidate at the Indian Institute of Technology in Delhi. We highlight this new dimension of the neurological impact of COVID -19 and report significant abnormalities in COVID survivors.”

The researchers analyzed sensitivity-weighted imaging data from 46 COVID-19 recovered patients and 30 healthy controls. Imaging was done within six months of recovery. Among patients with persistent COVID, the most commonly reported symptoms were fatigue, trouble sleeping, lack of concentration, and memory problems.

“Changes in the susceptibility values ​​of brain regions may be indicative of changes in local composition,” Mishra said. “Susceptibility may reflect the presence of abnormal amounts of paramagnetic compounds, while lower sensitivity may be caused by abnormalities such as calcification or lack of iron-containing paramagnetic molecules. “

Magnetic resonance imaging results showed that patients recovering from COVID-19 had significantly higher susceptibility values ​​in the frontal lobes and brain stem compared with healthy controls. The clusters obtained in the frontal lobes mainly show white matter differences.

“This brain region has been linked to fatigue, insomnia, anxiety, depression, headaches and cognitive problems,” Mishra said.

Parts of the left orbital inferior frontal gyrus (a critical area for language understanding and production) and the inferior right orbital frontal gyrus (involved in various cognitive functions including attention, memory, motor and visual mechanisms, as well as social cognitive processes) and the vicinity White matter areas made up frontal lobe cluster.

The researchers also found a significant difference in the right ventricular region of the brain stem. This region is involved in many important body functions, including working with the endocrine system to release hormones and transmit sensory and motor signals to the body. cortical And regulate Circadian rhythms (sleep-wake cycle).

“This study shows that serious long-term complications can be caused by the coronavirus, even months after recovery,” Mishra said. “Current findings are from a small time window. However, longitudinal timelines of a few years will shed light on whether any permanent changes exist.”

The researchers are conducting a longitudinal study in the same group of patients to determine if these brain abnormalities persist over a longer time frame.

Co-authors are Rakibul Hafiz, PhD, Tapan Gandhi, PhD, Vidur Mahajan, MBBS, Alok Prasad, MD, and Bharat Biswal, PhD.

quote: MRI showing significant post-COVID brain abnormalities (2022, November 21) retrieved November 21, 2022 from https://medicalxpress.com/news/2022-11-mri-reveals-respect -brain-abnormalities.html

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