In a first study of its kind, researchers at Tel Aviv University fitted nearly 5,000 Israelis with smartwatches and tracked their physiological parameters for more than two years. Of those followed, 2,038 received a booster dose of the coronavirus vaccine, allowing the researchers to objectively compare measures before and after the participants received the vaccine, and at the same time. confirm the safety of the vaccine.
In addition, in collaboration with the Kahn Sagol Maccabi Center for Research & Innovation (KSM—Maccabi Health Services’ research and innovation institute), the researchers tested the safety of the booster with how to analyze the anonymous medical records of 250,000 members of the Maccabi Health Service (without identifying the details) and with the approval of the Helsinki Commission. From the analysis of this large amount of data, researchers were able to assess vaccine safety from three aspects: subjective—what participants reported, objective—what the clock develops. present and clinical—what the doctor diagnoses.
Research conducted by Ph.D. student Matan Yechezkel under the supervision of Professor Dan Yamin, Head of the Epidemic Research Laboratory, and in collaboration with Professor Erez Shmueli, Head of the Big Data Laboratory, all from the Fleischman Faculty of Engineering at the University study in Tel Aviv. Other collaborators are Dr. Tal Patalon and Dr. Sivan Gazit, Director and Deputy Director of KSM, respectively, as well as Dr. Amichai Painsky and Ms. Merav Mofaz from Tel Aviv University. The results of the study were published on Respiratory medicine Lancet.
“We wanted to test the safety of the booster vaccine against the coronavirus. We conducted a large-scale trial that lasted two years. clinical research During that time we have equipped 4,698 Israelis with smartwatches. Smartwatches are used to monitor a number of parameters such as heart rate, changes in heart activity, sleep quality, daily steps taken, etc,” said Professor Yamin.
“Additionally, the participants were asked to fill out a daily questionnaire about their health in a custom app we developed. Finally, we analyzed the data on the patients. potential unusual events from the medical records of a quarter of a million randomly selected, anonymous, insured members of Maccabi Health Services.”
Because the medical records date the booster vaccine, the researchers were able to compare the condition of the vaccinated patients with their baseline from 42 days before vaccination with condition 42 days after vaccination. Data was obtained from questionnaires, smart meters and records of the Maccabi Health Foundation.
“We saw clear and significant changes after vaccination, such as an increase in heart rate compared to the heart rate measured before vaccination, and then we saw a return to muscle levels. participants’ copy, that is, the pulse level after vaccination returned to normal. The previous level after six days. Therefore, our study confirms the safety of the vaccine,” said Professor Yamin. speak.
“The study also allows us to compare subjective and objective indicators and medical diagnosis of the same participant who received the first booster and a few months later the second booster. We found no difference in physiological responses recorded by the smartwatch or reported by the app participants.”
In fact, smartwatches are even more accurate.
The researchers note that “the most surprising finding was that the watches were more sensitive than the people they were monitoring. Many participants reported fatigue, headaches, etc. and after two or three days say they feel fine and healthy.” .Conversely, from testing their watches, we have seen noticeable changes in heartbeat that continued for a few more days.
“There were also vaccination participants who did not report any side effects and certainly experienced physiological changes, based on the data from their smartwatch. In other words, we know. found that smartwatches were more sensitive to changes in general sensation than the participants themselves.”
In the medical literature, 25 unusual side effects from the COVID vaccine were reported, and the researchers looked for rare cases of myocarditis (inflammation of the heart muscle) and pericarditis. . Professor Yamin and his colleagues examined the frequency of these unusual side effects among a quarter of a million Maccabi members and found no increase in serious events of any kind. related to vaccination.
Professor Yamin said: “If the watch reports any small changes in muscle and the participant reports only the significant changes he feels, then the medical records tell us about the events. physician-diagnosed abnormalities as well as possibly vaccination-related hospitalizations, with an emphasis on cardiovascular events We comprehensively analyzed all 25 of these abnormalities. side Effectsand we did not see an increased incidence in those receiving booster shots.
“We found the vaccine to be safe to use. The smartwatch’s sensors ‘feel’ that the vaccine is safe, the person giving the vaccine reports that the vaccine is safe and ultimately safe. , doctors determined that the vaccine is safe.The study results have far-reaching implications regarding the objective testing of Vaccine future safety.”
Matan Yechezkel et al., Safety of the COVID-19 vaccine BNT162b2 mRNA (second booster): a prospective and retrospective cohort study, Respiratory medicine Lancet (2022). DOI: 10.1016/S2213-2600(22)00407-6
Tel Aviv University
quote: Tracking of heart measurements via smart watch showing COVID booster vaccine is safe (2022, 28 Dec) retrieved 28 Dec 2022 from https://medicalxpress.com/ news/2022-12-heart-smartwatches-covid-booster-vaccine.html
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