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Modulating immune memory can help the immune system fight disease, study finds


Immune memory modification may help the immune system fight disease, MU study suggests

MU researchers Credit: University of Missouri

Scientists have long sought to better understand the human body’s immune responses that occur in various diseases, including cancer and inflammatory diseases.

In a recent study at the University of Missouri, Emma Teixeiro, an associate professor at MU School of Medicine, and her team analyzed how immune memory — the body’s memory Immune System retained after infection or vaccination provides protection against reinfection—created and maintained, as well as the role of inflammation in the formation of that immune memory.

“Our immune system protects us from disease, but it is a very complex system with many interactions happening and if things happen,” said Teixeiro, who works at the NextGen Institute for Precision Health. If it’s dysregulated, it can actually play a role in disease.” MU campus. “So join me research focus on better understanding how these immune responses can be generated and controlled, especially by looking at the important role T cells play, as T cells help protect the body from infection and may play a role in attacking cancer.”

Use one mouse modelresearchers have engineered many different strains of pathogenic bacteria that increase inflammation levels through the gene promoter interferon—or STING—a protein inside T cells. While many scientists attribute the increase to This inflammation leads to a stronger immune response and, therefore, stronger immune memory, Teixeiro and her team found just the opposite: impaired immune memory.

“Some scientists in the field believe that STING activation could be targeted to improve cancer vaccines or immunotherapy, so it’s a fundamental understanding of all the mechanisms,” said Teixeiro. Ongoing interactions are important to reduce the likelihood of undesirable effects or harmful side effects.” “We want to better understand how to regulate immune memorythis has implications for potential vaccines or immunotherapy that activate T cells in a way that will hopefully enhance long-term memory, so that our bodies are protected from disease according to time.”

Although her research is fundamental in nature, Teixeiro’s findings have the potential to contribute to the development of more effective treatments to help patients with cancer, chronic obstructive pulmonary disease (COPD), infant-onset STING-associated vascular disease (SAVI), asthma, and other chronic inflammatory syndromes.

“The pursuit of knowledge is what fuels my curiosity as a scientist,” says Teixeiro. “While many questions remain to be answered, this study is a small step in the right direction and I am proud to be a part of it.”

“STING controls memory T-cell activity during infection through T-cell and Indoleamine-pyrrole 2,3-dioxygenase (IDO)-dependent mechanisms” recently published. in PNAS. Study co-authors include Michael Quaney, Curtis Pritzl, Rebecca Newth, Karin Knudson, Vikas Saxena, Caitlyn Guldenpfennig, Diana Gil, Chris Rae, Peter Lauer, Mark Daniels and Dezzarae Luera.

More information:
Michael J. Quaney et al., STING controls memory T-cell activity during infection through IDO-dependent and T-cell-dependent mechanisms, Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2205049120

quote: Immune memory regulation can help the immune system fight disease, study shows (2023, Jan. 20) retrieved Jan. 20, 2023 from https://medicalxpress.com/news /2023-01-immunological-memory-immune-disease.html

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