Identified factors causing hearing loss in neonates with congenital cytomegalovirus disease

ID'd factor for hearing loss in infants with congenital cytomegalovirus

According to a study published online on December 29 in the journal JAMA Otolaryngology-Head & Neck Surgery.

Elise De Cuyper, MD, from Ghent University in Belgium, and colleagues conducted a cross-sectional study of infants infected with cCMV from six primary and tertiary hospitals over 15 years (from 1 May). 1 2007 to 7 February 2022) to identify independent risk factors for cCMV-associated congenital disease hearing loss.

The researchers found that 416 and 617 (40.3 and 59.7 percent) of the 1,033 Infant included in the study were diagnosed with symptomatic cCMV infection and asymptomatic cCMV infection, respectively. Overall, 15.4% of patients had congenital hearing loss, 50.3% of whom had isolated hearing loss. Three independent factors for congenital hearing loss were identified in a regression model: petechiae at birth, periventricular cysts. Magnetic Resonance imaging (MRI) and seroconversion in the first trimester (adjusted odds ratios, 6.7, 4.6, and 3.1, respectively). Patients with normal hearing had a lower viral load than patients with congenital hearing loss (mean viral load, 447.0 vs 1,349.5 copies/mL).

“Infants with cCMV infection with petechiae at birth, periventricular cysts on MRI, or seroconversion during the first trimester have a higher risk of congenital hearing loss,” the authors write. “These risk factors can be used by clinicians to advise parents in the pre- and postnatal period about the risk of congenital hearing loss.”

More information:
Elise De Cuyper et al., Risk factors for hearing loss at birth in neonates with congenital cytomegalovirus infection, JAMA Otolaryngology–Head & Neck Surgery (2022). DOI: 10.1001/jamaoto.2022.4109

Albert H. Park, Detection of Hearing Loss in Children with Congenital Cytomegalovirus—Finding a Needle in the Bottom of a Tank, JAMA Otolaryngology–Head & Neck Surgery (2022). DOI: 10.1001/jamaoto.2022.4155

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quote: Identified factors causing hearing loss in neonates with congenital cytomegalovirus (2022, 30 December) retrieved 30 December 2022 from 12-factors-loss-newborns-congenital-cytomegalovirus.html

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