Most cases of pancreatic cancer arise in approximately 55-80% of adults over the age of 40, who are estimated to have precancerous silent pancreatic lesions.
A study published in Nature Communications showed that precancerous pancreatic lesions in mice, similar to those in humans, contain higher levels of the transcriptionally proliferative peroxisome-activated delta receptor (PPARδ).
A high-fat diet may promote the growth of cancer cells in the pancreas
PPARδ regulates the expression of many important genes that influence biological processes such as lipid metabolism and carcinogenesis. Activation of PPARδ accelerates the progression of precancerous lesions to pancreatic cancer.
“We became interested in studying the effects of PPAR on pancreatic cancer angiogenesis because our previous observations showed that PPAR strongly promotes gastrointestinal cancers,” said Shureiqi. but little is known about the role of PPARδ in the development of pancreatic cancer”.
Activation of PPARδ correlates with a high-fat diet, which is associated with an increased risk of pancreatic cancer in humans and animal models. The high-fat diet is enriched with fatty acids that are natural ligands of PPARδ.
Other synthetic forms of the PPARδ ligand are found in exercise supplements, intended to enhance physical performance and endurance.
These supplements were originally designed by pharmaceutical companies to encourage the body to use more fat and to treat noncancerous conditions such as obesity and hyperlipidemia. Since then, many companies have discontinued production due to the potential side effects of cancer.
Although studies on how PPARδ affects colorectal cancer began in 1999 and pharmaceutical companies stopped developing the synthetic PPARδ ligand, unregulated internet stores still sell substances such as Cardarine. The ad was mainly marketed to young people, claiming it would help them build muscle endurance and burn fat.
Muscle-strengthening drug improves endurance along with cancer risk
Initially, the researchers found that these supplements reduced fatigue in mice. This news made it to the major media, who nicknamed it “exercise in a pill”.
Unfortunately, what the media doesn’t cover is the dark side of it. Like muscle cells, the synthetic PPARδ ligand also helps cancer cells get more energy from fat as a fuel source.
Animal models have repeatedly shown a close relationship between PPARδ and cancer promotion in the case of colorectal cancer and gastric cancer. Now we are having more information about how it affects pancreatic cancer.
Future development of effective agents to block PPARδ activation may represent a novel approach to halt the progression of precancerous lesions to pancreatic cancer.
Limiting exposure to a high-fat diet may also be considered for those with high rates of precancerous pancreatic lesions. But for now, the widespread sale and use of those sports enhancers causes the most pressing concern.
We’re trying to get the message across that it’s not a good idea to use those substances. It can enhance muscle endurance, but it also enhances energy utilization and cancer growth.