Consuming more fish may increase the risk of melanoma

Researchers from Brown University, USA found that, compared with people with an average daily fish intake of 3.2 grams,

They also found that people with an average daily fish intake of 42.8 grams of fish had an increased risk of developing abnormal cells only in the outer layer of the skin – known as stage 0 melanoma or melanoma. topical factor – a 28% increase over those with an average daily intake of 3.2 grams of fish.


One serving of fish is about 140 grams of cooked fish.

Why does eating fish increase skin cancer?

To examine the relationship between fish intake and melanoma risk, the authors analyzed data collected from 491,367 adults recruited from across the United States for the Diet and Health Study. the NIH-AARP diet from 1995 to 1996.

Participants, average age 62, reported how often they ate fried fish, non-fried fish and tuna in the previous year as well as their portion sizes.

The researchers calculated the incidence of new malignancies developing over an average period of 15 years using data obtained from cancer registries. They took into account sociodemographic factors, as well as the participants’ BMI, physical activity level, smoking history, daily alcohol intake, caffeine and calories, family history of cancer, and average UV radiation levels in their local area. 5,034 participants (1.0%) developed melanoma during the study period and 3,284 (0.7%) developed stage 0 melanoma.

The researchers found that eating a lot of non-fried fish and tuna was associated with an increased risk of melanoma and stage 0 melanoma. People with an average daily intake of tuna were 14.2 grams had a 20% higher risk of melanoma and a 17% higher risk of stage 0 melanoma, compared with those with an average daily tuna intake of 0.3. grams.

Eating an average of 17.8 grams of non-fried fish per day was associated with an 18% higher risk of melanoma and a 25% higher risk of stage 0 melanoma. compared with the average consumption of 0.3 grams of non-fried fish per day. The researchers did not identify a significant link between fried fish consumption and the risk of melanoma or stage 0 melanoma.

“We speculate that our findings may be due to contaminants in fish, such as polychlorinated biphenyls, dioxins, arsenic and mercury,” said Eunyoung Cho. Higher fish intakes are associated with higher levels of these pollutants in the body and have identified an association between these pollutants and a higher risk of skin cancer. We note that our study did not investigate the concentrations of these contaminants in the participants’ bodies and so further research is needed to confirm this relationship.”

The researchers caution that the observational nature of their study does not allow conclusions to be drawn about a causal relationship between fish intake and melanoma risk. They also did not take into account some risk factors for melanoma, such as number of moles, hair color, history of severe sunburn, and sun-related behaviors in their analyses. surname. In addition, because average daily fish intake was calculated at the start of the study, it may not be representative of the participants’ lifetime diets.

The authors suggest that future research is needed to investigate which fish compositions may contribute to the observed association between fish intake and melanoma risk and any What biological mechanism underlies this. Currently, they do not recommend any changes to fish consumption.

Source: Eurekalert

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